A weird genetics question

Just wondering how a triple helix or a quadruple helix DNA would affect a creature who DNA is completely composed of either the triple or quadruple helix DNA? I've just had an idea in my head and wanted to know if it worked any differently then double helix DNA.

23,160 views 6 replies
Reply #1 Top

It would probably just cause problems.

 

It can work in theory beacuse the "coding" part of DNA is just really 1 of the strands, the second strand is just there to make copying and error preventing etc easier. But adding more moving parts just makes errors that much more likely.

 

It would be more intersting to have more base pairs then to have more helixes. 

 

Having more then 1 coding strand would cause problems because both strands would have to code for something non-detrimental at the same time, which is unlikely to work out, or you would need to evolve 2 seperate transcode mechanisms (1 different one per strand). Having 3+ helixes also would remove the incredible space saving self folding up DNA can do, which is bad for error prevention.

 

edit: i did find this on wikipedia tho http://en.wikipedia.org/wiki/G-quadruplex might be a fun read.

Reply #2 Top

Wikipedia is never wrong. Lol

Reply #3 Top

Quoting EleventhStar, reply 1

It would probably just cause problems.

 

It can work in theory beacuse the "coding" part of DNA is just really 1 of the strands, the second strand is just there to make copying and error preventing etc easier. But adding more moving parts just makes errors that much more likely.

 

It would be more intersting to have more base pairs then to have more helixes. 

 

Having more then 1 coding strand would cause problems because both strands would have to code for something non-detrimental at the same time, which is unlikely to work out, or you would need to evolve 2 seperate transcode mechanisms (1 different one per strand). Having 3+ helixes also would remove the incredible space saving self folding up DNA can do, which is bad for error prevention.

 

edit: i did find this on wikipedia tho http://en.wikipedia.org/wiki/G-quadruplex might be a fun read.
Ok. So basicly anything more then a double helix would, from what we know, have more errors occur more often, and would take more space then a double helix.

Reply #4 Top

What about six, same number as carbon, would that be a sweet spot of stability? (come on all you intellectuals out there I'm to lazy to google it!)

 

DARCA ;)

Reply #5 Top

Quoting DARCA1213, reply 4

What about six, same number as carbon, would that be a sweet spot of stability? (come on all you intellectuals out there I'm to lazy to google it!)

 

DARCA ;)

 

I suppose a civilization more advanced then ours could engineer something like that, including the mechanisms needed for repair and transcoding etc,  but the only similarities it would have with DNA is that it would encode genetic information.

I also don't know what the point would be. Human DNA has 64 possible codons which only code for 20 animo acids and a few stop codons, so you already have more capacity then you need with just 4 base pairs and 3 bases per codon. You would have to more then double the amount of animo acids your organism uses before you would have any real need for either more bases or base triplets.

Reply #6 Top

Quoting EleventhStar, reply 5


Quoting DARCA1213,

What about six, same number as carbon, would that be a sweet spot of stability? (come on all you intellectuals out there I'm to lazy to google it!)

 

DARCA ;)



 

I suppose a civilization more advanced then ours could engineer something like that, including the mechanisms needed for repair and transcoding etc,  but the only similarities it would have with DNA is that it would encode genetic information.

I also don't know what the point would be. Human DNA has 64 possible codons which only code for 20 animo acids and a few stop codons, so you already have more capacity then you need with just 4 base pairs and 3 bases per codon. You would have to more then double the amount of animo acids your organism uses before you would have any real need for either more bases or base triplets.

Ok. Thanks. Time to rethink my idea now.