Frankly, I don't know what they could possibly do with DNF. Although it was one of the early adopters of the FPS alien-shooter genre, its original premise is now so cliche and overdone that it'd be suicide to stick to the original. I don't see it achieving anything noteworthy.
I know I'd play it (eventually) only for the crude adult humour, the strippers and Duke's classic one-liners...Sure it's lie any other FPS, but Duke got personality, instead of being yet another voiceless, faceless protsagonist like every other FPS..even when they do have a voice, they suck most of the time