Absolutely. I assume you're referring to the Tyrant bug specifically?
So here is a shot of my diplomacy screen before taking Indoctrinate:

I'm already allied with the Ice Lords in this example, and at 4/5 favor with the Swamp Giants and 3/5 with the Keepers of the Flame. Now I take Indoctrinate...

This is what my diplomacy screen looks like AFTER taking Indoctrinate, but BEFORE moving to the next turn. Hovering over any of the favor bars shows a net +2 change to favor, and I even have the blue banner signifying an alliance with both the Giants and Keepers now. (Note that the +2 favor gain is more than the +1 gain advertised in the Indoctrinate skill description.)
However, on the next turn, when favor is normally updated, the favor totals, and the diplomacy screen in general, revert back to the way they were in the first screenshot. No alliances are formed or anything, it just does nothing.