Well it can work in your left hand, but obviously the side buttons are made for right-hand use.
Of that I'm sure, but I'm concerned with fit into palm - shallow/full, titled/even, symmetric or not, etc. Not that I don't like symmetric mouse idea, but those I've tried weren't more comfortable (or at least on par) than some right-handed only designs.
I must admit, I almost give up on the idea to find decent mouse for lefty, as I gave up on idea finding many other tools for lefties, resulting in me being able to do things with both hands equally bad.
Thanks for you time, and let my poking you with these questions be greatest problem you'll have with this mouse.