There is some strange stuff going on with ZoC, and Bloom of Twilight not working properly. Essentially with big ZoC you are guaranteed settling spots after a while next to your original city, while BoT that should do it at a cost, does not work. I think it has been like this since 1.2, but not sure.
(Just for reference, My Huge custom map, by then end I had 60 cities.. on Desert tileset, something is very wrong with that)