Not a game breaker, but When you click on the quest location icon that shows up on the left hand side of the GUI, it moves to the on-map location of that quest.  After saving and reloading my game, it seemed to have forgotten the locations of those quests.  In the game I have been playing I had about three active quests.  It's quite nice to have the game show me where they are.  My guess is that some small piece of information is not being written out and read in during the save process.  After loading the game from the save, clicking on those icons didn't do anything.