I've been playing since the 1.0 version and have only had one minor issue and have well over 24 total hours into the game now. I thought I would show my settings and you could try them to see if it helps stop your issues.

First the Video options of the game:

Resolution @ 1400x1050     Low Res Shadows

Use Fullscreen Numerous x 2 = Amount of ground cover

Anti Alias OFF 

Normal Unit Scale

Limit Frame Rate: ON

Limit Frame Rate to 60

GFX:Disable Depth on Field: ON

Max Tex Atlas Size: 1024x512

Max Mip Map Levels: DEFAULT

Scale Units while Zooming: OFF

Font Smoothing: ON

Stylized Lighting: ON

Softness Adv Light @ 75

Then GAME SETTINGS:

Skip Intro: ON                                                    

Use Tooltips: ON

Tool Tip Delay : 0.02

Draw Grid: ON

Smart Player Colors : OFF

Clot Map Only: OFF

Cloth Map Zoom: 80

Editor Cloth Zoom : 70

Cloth Flow Brightness 20

Clip Cursor in Fullscreen: OFF

Edge Scroll Speed 100

Edge Scroll Delay 0.10

Cloth Color Intensity 100

Disable Zoom Limit : ON

Enable Auto Turn: OFF

Enable Quick Move: OFF

Use Localized Data ON

Use Mods: OFF

Flollow Select Unit ON

Auto Select Unit ON

Show City Level upgrade ON

Zoom to Cursor ON

Enable City Build Mode Zoom: OFF

Enable Autosave ON

Set autosave to 1

Tact Battle Threshold set to 1

Enable Janusk ON

Automove Cursor in Tactical OFF

Screenshot JPG

Good luck hope this helps somebody.